Theyre easy and wonderful together.

But Rhimes recognizes that not everyone would want to see the friends together.

If you talk to Ellen and Justin theyll go, Ew!

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Credit: Mitch Haaseth/ABC

because theyre like brother and sister, Rhimes says.

But I think its because those two actual people have 13 years of history together.

Theyre very, very much intertwined; theyre family.

So it feels really easy like family, and theres something beautiful about that.

Chambers concurs: It did surprise me, because I never saw that happening.

I know we did an episode where it was like What if?

so we got to see a little bit of it, but yeah, its surprising.

Hey, this is Shondaland, you know?

Its really damaging on so many levels.

An interesting storyline to play this year is not really knowing who Alex is.

You think people have come so far.

Theres that adage that people dont change, but people do change.

Itll be fun to play.

For Alex, he will regress to the gruff character of the early days.

Shes covering for him, Chambers adds.

Bloods thicker than water, but theyre not even blood, they are like siblings.

I think shell do the right thing, but if Alex does, thats another question.

Alex is pretty complicated at times.

All that said, would Rhimes ever consider pairing Meredith and Alex on a romantic level?

Ive learned to never say never at this point, Rhimes says.

I always thought the show would end at season 2, 3, 4 or 5.

Then everyone gets mad because I said something was definitely going to happen.

So Im never going to say never at this point.

Greys Anatomyreturns Thursday, Sept. 22 at 8 p.m.