In matters of the heart, doctors should know best, right?

Grey’s Anatomyreturns on Sept. 22 on ABC.

Call me crazy, but I smell a little drama.

Grey’s Anatomy: Romance abounds in season 13

Bob D’Amico/ABC

But don’t expect a cat fight, per se.

“That relationship is going to be deeply affected,” Rhimes says.

But Alex will be just as hurt over learning that Jo isn’t who she says she is.

Meredith-Riggs-Maggie (Kelly McCreary, Ellen Pompeo, and Martin Henderson

Vivian Zink/ABC

“Those feelings are still there,” Rhimes says.

Theres some flirting that happens.

We think we can have a little fun with it versus being dark and grim."

Jo and Alex (Justin Chambers and Camilla Luddington)

Mitch Haaseth/ABC

Watching him deal with this will be very interesting."

“That feels rare on television.

Theres something delightful about watching this couple that you know is going to make it struggle through life.

April and Jackson (Sarah Drew and Jesse Williams)

Eric McCandless/ABC

Were absolutely going to see it, Rhimes says.

Amelia and Owen (Caterina Scorsone and Kevin McKidd)

Byron Cohen/ABC

Bailey and Ben (Chandra Wilson and Jason George)

Mitch Haaseth/ABC

Arizona (Jessica Capshaw)

Tony Rivetti/ABC